Protein Details: Aquaporin-2

Protein ID

ICDB_Pro_0017

Protein Name

Aquaporin-2

Gene Name

AQP2; PBANKA_1427100

Organism

Plasmodium berghei (strain Anka)

Length

595 amino acids

AlphaFoldDB

AF-A0A509AUY5-F1-model_v4.pdb

Function

Required for sporozoite development in the mosquito vector . Required for parasite transmission to the mammalian host .

Sequence

MKTKGRLLLYINYAKYAIKACFKIIINHIKDIREEINVKSFSKYKYNFLFEFIGSFIFVFLISVYMLNSNQNEEYIIKHLNQINPYKKNDIFINEVNIHNNDINGSEDIRNASGIKNINSINDVKMYEARALLNQGNKQLKEQNDTIFEKNKINNTEKIENSISEEKEQTIPNTNEDSTTIVNDNKREEDEVTNIGEKNDKINEAAYIISLPKDSNKEKLTKDIDEVIFKDKVNEYSKIKLDDINNMDLKKFDDIKILKDSSNKNNSNHAIYSFFGCLIYVLFIILGAHINPAYTYALWLIEPQKYGFVITTLYATFQYIGGILASILCAHIYGSIFIYSLLPRKHIMKTFLCEFVSTFLLTILLLSFYNYKKLFKEENQNEEEFSFNKEKIKNMSSLYSSHSFEDIYEYDIFSTYSTNSTNNNKYKKLFIYFDNKYIKYIINHIFYLLFIFFSLLFFVFVTNTTLNPMFSTSTLCTYLYFKYVQSNNSFNFFSIFFSFLSLGKIIQIIIFYIKSLPLWIGPYAGSACATFFMKLFKDNNEEIVNVIDTNVYSHNRTKEKMPLINTNNMNHNAYLEEYNDHICYNSNNYLNYKIF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1186/s12915-014-0086-0; 10.1016/j.chom.2023.08.010; 10.1073/pnas.2304339120